منابع مشابه
Novel α-MSH Peptide Analogues with Broad Spectrum Antimicrobial Activity
Previous investigations indicate that α-melanocyte-stimulating hormone (α-MSH) and certain synthetic analogues of it exert antimicrobial effects against bacteria and yeasts. However, these molecules have weak activity in standard microbiology conditions and this hampers a realistic clinical use. The aim in the present study was to identify novel peptides with broad-spectrum antimicrobial activi...
متن کاملCombination Effects of Antimicrobial Peptides
Antimicrobial peptides (AMPs) are ancient and conserved across the tree of life. Their efficacy over evolutionary time has been largely attributed to their mechanisms of killing. Yet, the understanding of their pharmacodynamics both in vivo and in vitro is very limited. This is, however, crucial for applications of AMPs as drugs and also informs the understanding of the action of AMPs in natura...
متن کاملEffects of Hydrophobicity on the Antifungal Activity of α-Helical Antimicrobial Peptides
Department of Biochemistry & Molecular Genetics, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA Department of Medicine, Radboud University, Nijmegen University Centre for Infectious Diseases, Nijmegen, The Netherlands Department of Medical Microbiology, Radboud University, Nijmegen University Centre for Infectious Diseases, Nijmegen, The Netherlands Department of Micro...
متن کاملMechanism of Anticancer Effects of Antimicrobial Peptides
Antimicrobial Peptides (AMPs) were first known as a group of innate immune products that mainly targets on the invading pathogens among multiple species. The essential mechanisms of action of AMPs toward microbial cells have been reported as electrostatic attraction and hydrophobic interaction between AMPs (cationic AMPs) and microbial cell membranes. These effects also contribute to the potent...
متن کاملEffects of antimicrobial peptides on methanogenic archaea.
As members of the indigenous human microbiota found on several mucosal tissues, Methanobrevibacter smithii and Methanosphaera stadtmanae are exposed to the effects of antimicrobial peptides (AMPs) secreted by these epithelia. Although antimicrobial and molecular effects of AMPs on bacteria are well described, data for archaea are not available yet. Besides, it is not clear whether AMPs affect t...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2000
ISSN: 0741-5400
DOI: 10.1002/jlb.67.2.233